BDBM50020849 8-(3-Amino-phenyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione::CHEMBL11033

SMILES Cn1c2nc([nH]c2c(=O)n(C)c1=O)-c1cccc(N)c1

InChI Key InChIKey=YHFUPFABICLMEE-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50020849   

TargetAdenosine receptor A1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50020849(CHEMBL11033 | 8-(3-Amino-phenyl)-1,3-dimethyl-3,7-...)
Affinity DataIC50: 10nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50020849(CHEMBL11033 | 8-(3-Amino-phenyl)-1,3-dimethyl-3,7-...)
Affinity DataIC50: 10nMAssay Description:Binding affinity against adenosine A1 receptor in rat brain membrane preparations using N6-[3H]cyclohexyladenosine as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50020849(CHEMBL11033 | 8-(3-Amino-phenyl)-1,3-dimethyl-3,7-...)
Affinity DataKi:  900nMAssay Description:Antagonism of cyclic [3H]AMP accumulation elicited by 15 uM 2-chloroadenosine in [3H]adenine-labeled guinea pig cerebral cortical slices at A2 recept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50020849(CHEMBL11033 | 8-(3-Amino-phenyl)-1,3-dimethyl-3,7-...)
Affinity DataKi:  1.10E+3nMAssay Description:Antagonism of binding of 1 nM [3H]cyclohexyladenosine to adenosine A1 receptors on rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed