BDBM50021718 CHEMBL3298678

SMILES OC[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(Cl)c(F)c1

InChI Key InChIKey=OJRJASQFNLOAKZ-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50021718   

TargetMitogen-activated protein kinase 1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50021718(CHEMBL3298678)
Affinity DataKi:  0.150nMAssay Description:Binding affinity to ERK2 (unknown origin) using Ulight-MBP as substrate assessed as inhibition constant preincubated for 30 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50021718(CHEMBL3298678)
Affinity DataKi:  0.600nMAssay Description:Inhibition of 6-His tagged human ERK2 expressed in Escherichia coli measured over 30 mins by competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50021718(CHEMBL3298678)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021718(CHEMBL3298678)
Affinity DataIC50: 10nMAssay Description:Inhibition of Cdk2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
LigandPNGBDBM50021718(CHEMBL3298678)
Affinity DataKi:  16nMAssay Description:Binding affinity to CDK2/Cyclin E1 (unknown origin) using Ulight-MBP as substrate assessed as inhibition constant preincubated for 30 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50021718(CHEMBL3298678)
Affinity DataIC50: 25nMAssay Description:Inhibition of ERK2 in human HepG2 cells assessed as P90RSK phosphorylation at Ser380 after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed