BDBM50021739 CHEMBL3297858::US9133187, II-43

SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CNS(C)(=O)=O)c1ccc(F)c(Cl)c1

InChI Key InChIKey=VVFRSXHTWWXYBO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50021739   

TargetMitogen-activated protein kinase 1(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021739(CHEMBL3297858 | US9133187, II-43)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021739(CHEMBL3297858 | US9133187, II-43)
Affinity DataIC50: 7.10nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021739(CHEMBL3297858 | US9133187, II-43)
Affinity DataIC50: 917nMAssay Description:Inhibition of ERK2 in human HepG2 cells assessed as P90RSK phosphorylation at Ser380 after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed