BDBM50027456 CHEMBL3329404

SMILES CC(C)(C)c1cc(NC(=O)Cc2cccc(Oc3ccc4nccn4n3)c2)no1

InChI Key InChIKey=VRNLJQHAJGRGJN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50027456   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50027456(CHEMBL3329404)
Affinity DataIC50: 750nMAssay Description:Inhibition of RET (unknown origin) pre-incubated for 60 mins before substrate addition in presence of 9 uM ATP by microfluidic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50027456(CHEMBL3329404)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of RET C634R mutant (unknown origin) expressed in rat RAT1 cells assessed as reduction in Tyr1062 phosphorylation at 0.5 to 10 uM incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50027456(CHEMBL3329404)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of RET C634R mutant (unknown origin) expressed in rat RAT1 cells assessed as reduction in Tyr905 phosphorylation at 0.5 to 10 uM incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed