BDBM50027457 CHEMBL3329397

SMILES CC(C)(C)c1cc(NC(=O)Cc2ccc(cc2)-c2ccc3nccn3c2)no1

InChI Key InChIKey=ODVKEUNDHWFSOX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50027457   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50027457(CHEMBL3329397)
Affinity DataIC50: 210nMAssay Description:Inhibition of RET (unknown origin) pre-incubated for 60 mins before substrate addition in presence of 9 uM ATP by microfluidic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50027457(CHEMBL3329397)
Affinity DataIC50: 250nMAssay Description:Inhibition of RET C634R mutant (unknown origin) expressed in rat RAT1 cells assessed as reduction in Tyr1062 phosphorylation at 0.5 to 10 uM incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50027457(CHEMBL3329397)
Affinity DataIC50: 250nMAssay Description:Inhibition of RET C634R mutant (unknown origin) expressed in rat RAT1 cells assessed as reduction in Tyr905 phosphorylation at 0.5 to 10 uM incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50027457(CHEMBL3329397)
Affinity DataIC50: 380nMAssay Description:Inhibition of RET (unknown origin) pre-incubated for 20 mins before substrate addition in presence of 9 uM ATP by microfluidic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50027457(CHEMBL3329397)
Affinity DataIC50: 420nMAssay Description:Inhibition of RET (unknown origin) pre-incubated for 3 mins before substrate addition in presence of 9 uM ATP by microfluidic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50027457(CHEMBL3329397)
Affinity DataIC50: 440nMAssay Description:Inhibition of RET (unknown origin) pre-incubated for 0 mins before substrate addition in presence of 9 uM ATP by microfluidic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed