BDBM50027481 (E)-1-(2,5-dihydroxyphenyl)-3-(2-hydroxyphenyl)-2-propen-1-one (13)::CHEMBL3335589

SMILES Oc1ccc(O)c(c1)C(=O)\C=C\c1ccccc1O

InChI Key InChIKey=NXTSNFDLQUTBRV-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50027481   

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Instituto De Qu£Mica M£Dica (Iqm-Csic)

Curated by ChEMBL
LigandPNGBDBM50027481(CHEMBL3335589 | (E)-1-(2,5-dihydroxyphenyl)-3-(2-h...)
Affinity DataEC50:  1.90E+3nMAssay Description:Positive allosteric modulation at human alpha7 nACHR expressed in Xenopus oocyte assessed as potentiation of 200 uM ACh-induced current at holding po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

LigandPNGBDBM50027481(CHEMBL3335589 | (E)-1-(2,5-dihydroxyphenyl)-3-(2-h...)
Affinity DataIC50: 4.18E+4nMpH: 4.5 T: 2°CAssay Description:The assay based on fluorescenceresonance energy transfer was carried out with BACE1 enzyme at pH 4.5 with a substrate, H-Lys(DABSYL)-SEVNLDAEFR-Gin-(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2017
Entry Details Article
PubMed