BDBM50028859 CHEMBL3342698

SMILES Fc1cccc(Cl)c1C(=O)Nc1ccc2cnn(-c3ccc(Br)cc3)c(=O)c2c1

InChI Key InChIKey=OLHAVUZFCRGFHC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50028859   

TargetProstaglandin E synthase(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50028859(CHEMBL3342698)
Affinity DataIC50: 50nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in IL-beta induced PGE2 release preincubated for 30 mins followed by IL-beta addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Y. B. Chavan College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50028859(CHEMBL3342698)
Affinity DataIC50: 179nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed