BDBM50028871 CHEMBL3342712

SMILES CC(C)C(=O)NCc1ccc(Cl)c(c1)-c1nc2cc(ccc2c(=O)[nH]1)-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=OVIIAFMCTRQPMZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50028871   

TargetProstaglandin E synthase(Human)
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50028871(CHEMBL3342712)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50028871(CHEMBL3342712)
Affinity DataIC50: 10nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as inhibition of IL-1beta-induced PGE2 production incubated for 30 mins prior to IL-1beta challeng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50028871(CHEMBL3342712)
Affinity DataIC50: 234nMAssay Description:Inhibition of mPGES-1 in human whole blood assessed as inhibition of LPS-induced PGE2 production after overnight incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed