BDBM50029934 5,6-Dimethoxy-2-[1-(4-nitro-benzyl)-piperidin-4-ylmethyl]-indan-1-one; hydrochloride::CHEMBL171048::CHEMBL543924

SMILES COc1cc2CC(CC3CCN(Cc4ccc(cc4)[N+]([O-])=O)CC3)C(=O)c2cc1OC

InChI Key InChIKey=ACJJKDSOGZQROR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50029934   

TargetAcetylcholinesterase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50029934(CHEMBL543924 | CHEMBL171048 | 5,6-Dimethoxy-2-[1-(...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Acetylcholinesterase activity in mouse brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetAcetylcholinesterase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50029934(CHEMBL543924 | CHEMBL171048 | 5,6-Dimethoxy-2-[1-(...)
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against acetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50029934(CHEMBL543924 | CHEMBL171048 | 5,6-Dimethoxy-2-[1-(...)
Affinity DataIC50: 1.91E+3nMAssay Description:Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50029934(CHEMBL543924 | CHEMBL171048 | 5,6-Dimethoxy-2-[1-(...)
Affinity DataIC50: 4.02E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 3 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
TargetCholinesterase(Horse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50029934(CHEMBL543924 | CHEMBL171048 | 5,6-Dimethoxy-2-[1-(...)
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of equine serum BuChE using s-butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
TargetCholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50029934(CHEMBL543924 | CHEMBL171048 | 5,6-Dimethoxy-2-[1-(...)
Affinity DataIC50: 8.58E+4nMAssay Description:Inhibition of human serum BuChE using s-butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed