BDBM50030687 CHEMBL339256::N-(3-{3-Butyl-4-[2'-(2-chloro-benzoylsulfamoyl)-3-fluoro-biphenyl-4-ylmethyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}-4-trifluoromethyl-phenyl)-propionamide

SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl

InChI Key InChIKey=YLFAFCSDNLBEIN-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50030687   

TargetType-2 angiotensin II receptor(RAT)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030687(CHEMBL339256 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Affinity DataIC50:  0.150nMAssay Description:In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030687(CHEMBL339256 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Affinity DataIC50:  0.430nMAssay Description:In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030687(CHEMBL339256 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was presen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030687(CHEMBL339256 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Affinity DataIC50:  0.130nMAssay Description:In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030687(CHEMBL339256 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Affinity DataIC50:  0.130nMAssay Description:Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-2 angiotensin II receptor(RAT)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030687(CHEMBL339256 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Affinity DataIC50:  0.310nMAssay Description:In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030687(CHEMBL339256 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Affinity DataIC50:  3.5nMAssay Description:In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030687(CHEMBL339256 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Affinity DataIC50:  0.130nMAssay Description:Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030687(CHEMBL339256 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Affinity DataIC50:  0.25nMAssay Description:In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was presen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed