BDBM50031614 CHEMBL3359758

SMILES NC1=N[C@@]2(CO1)c1cc(ccc1Oc1ncc(cc21)-c1ccc(cc1)C#N)-c1cccnc1F

InChI Key InChIKey=WNWBYUIGGUXYAA-SANMLTNESA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50031614   

LigandPNGBDBM50031614(CHEMBL3359758)
Affinity DataKi:  210nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells assessed as [3H]-dofetilide binding after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031614(CHEMBL3359758)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031614(CHEMBL3359758)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed