BDBM50031745 CHEMBL3360351::US10206907, Compound 225

SMILES O=C(Nc1nc2cccc(-c3ccc(CNc4ccccc4CC#N)cc3)n2n1)C1CC1

InChI Key InChIKey=MACBUYCJZAASKV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50031745   

TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031745(CHEMBL3360351 | US10206907, Compound 225)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Galapagos

US Patent
LigandPNGBDBM50031745(CHEMBL3360351 | US10206907, Compound 225)
Affinity DataIC50: 100nMAssay Description:Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Galapagos

US Patent
LigandPNGBDBM50031745(CHEMBL3360351 | US10206907, Compound 225)
Affinity DataIC50: 100nMAssay Description:Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent