BDBM50033412 CHEMBL3357671

SMILES [H][C@]12OCCC[C@]1(C)Oc1ccc(cc1[C@@]21COC(N)=N1)-c1cncnc1

InChI Key InChIKey=FAYFYCHHIWTMHI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50033412   

TargetBeta-secretase 1(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50033412(CHEMBL3357671)
Affinity DataIC50: 56nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50033412(CHEMBL3357671)
Affinity DataIC50: 89nMAssay Description:Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCathepsin B(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50033412(CHEMBL3357671)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of cathepsin D purified from human spleen after 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed