BDBM50034459 CHEMBL26522::N-(3,4-Dimethyl-isoxazol-5-yl)-4-fluoro-benzenesulfonamide

SMILES Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1C

InChI Key InChIKey=LTIZWYZGXKZSHV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50034459   

TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034459(N-(3,4-Dimethyl-isoxazol-5-yl)-4-fluoro-benzenesul...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50034459(N-(3,4-Dimethyl-isoxazol-5-yl)-4-fluoro-benzenesul...)
Affinity DataIC50: 6.70E+3nMAssay Description:Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEndothelin receptor type B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50034459(N-(3,4-Dimethyl-isoxazol-5-yl)-4-fluoro-benzenesul...)
Affinity DataIC50: 5.70E+4nMAssay Description:Binding affinity against human Endothelin B receptor in transfected COS 7 cell membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article