BDBM50034955 CHEMBL53605::N*2*-(3,4-Dichloro-phenyl)-9H-purine-2,6-diamine

SMILES Nc1nc(Nc2ccc(Cl)c(Cl)c2)nc2nc[nH]c12

InChI Key InChIKey=QUQWBNJQTLWIEB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50034955   

TargetDNA primase(HHV-1)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034955(N*2*-(3,4-Dichloro-phenyl)-9H-purine-2,6-diamine |...)
Affinity DataIC50: 850nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA primase(HHV-1)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034955(N*2*-(3,4-Dichloro-phenyl)-9H-purine-2,6-diamine |...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034955(N*2*-(3,4-Dichloro-phenyl)-9H-purine-2,6-diamine |...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition against coupled primase-DNA polymerase I assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034955(N*2*-(3,4-Dichloro-phenyl)-9H-purine-2,6-diamine |...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition against coupled primase-DNA polymerase I assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034955(N*2*-(3,4-Dichloro-phenyl)-9H-purine-2,6-diamine |...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition against DNA topoisomerase I by direct assay with activated DNA and 25 uM dNTPs including [3H]dTTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed