BDBM50036068 2-(1-Oxo-3-phenyl-1,9-dihydro-beta-carbolin-2-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide::CHEMBL325154

SMILES CC(C)C(NC(=O)Cn1c(O)c2nc3ccccc3c2cc1-c1ccccc1)C(=O)C(F)(F)F

InChI Key InChIKey=WCZJFJWJKABMHI-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50036068   

TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036068(2-(1-Oxo-3-phenyl-1,9-dihydro-beta-carbolin-2-yl)-...)
Affinity DataKi:  6.10nMAssay Description:In vitro inhibitory activity against human leukocyte elastase (HLE) mediated hydrolysis of the synthetic substrate MeOSuc-Ala-Ala-Pro-Val-pNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036068(2-(1-Oxo-3-phenyl-1,9-dihydro-beta-carbolin-2-yl)-...)
Affinity DataKi:  6.10nMAssay Description:The in vitro potency against elastase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036068(2-(1-Oxo-3-phenyl-1,9-dihydro-beta-carbolin-2-yl)-...)
Affinity DataKi:  430nMAssay Description:Inhibitory activity against bovine chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed