BDBM50036489 5-(2,5-Dimethoxy-phenylethynyl)-quinazoline-2,4-diamine::CHEMBL162312

SMILES COc1ccc(OC)c(c1)C#Cc1cccc2nc(N)nc(N)c12

InChI Key InChIKey=ZWXNKEWDCSTSQI-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50036489   

TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036489(5-(2,5-Dimethoxy-phenylethynyl)-quinazoline-2,4-di...)
Affinity DataKi:  140nMAssay Description:Inhibitory activity against Leu22-Phe mutant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036489(5-(2,5-Dimethoxy-phenylethynyl)-quinazoline-2,4-di...)
Affinity DataKi: >500nMAssay Description:Inhibitory compound against Wild-type human DHFR.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036489(5-(2,5-Dimethoxy-phenylethynyl)-quinazoline-2,4-di...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory activity against Toxoplasma gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036489(5-(2,5-Dimethoxy-phenylethynyl)-quinazoline-2,4-di...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory activity against Pneumocystis carinii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036489(5-(2,5-Dimethoxy-phenylethynyl)-quinazoline-2,4-di...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory activity against rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed