BDBM50038369 2-(2,5-Dimethoxy-4-trifluoromethyl-phenyl)-ethylamine::CHEMBL136354

SMILES COc1cc(c(OC)cc1CCN)C(F)(F)F

InChI Key InChIKey=LYXGNMLWYONZID-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50038369   

Target5-hydroxytryptamine receptor 2A(Human)
Gilgamesh Pharmaceuticals

US Patent
LigandPNGBDBM50038369(2-(2,5-Dimethoxy-4-trifluoromethyl-phenyl)-ethylam...)
Affinity DataKi:  15.8nMAssay Description:The binding affinities of disclosed compounds at the ketanserin binding site of the 5-HT2A receptor were determined in radioligand binding experiment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Gilgamesh Pharmaceuticals

US Patent
LigandPNGBDBM50038369(2-(2,5-Dimethoxy-4-trifluoromethyl-phenyl)-ethylam...)
Affinity DataKi:  25nMAssay Description:For all experiments, serotonin (5-HT) hydrochloride was used as a positive control, and an appropriate high affinity, cold ligand (e.g., mianserin hy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Cybin IRL

US Patent
LigandPNGBDBM50038369(2-(2,5-Dimethoxy-4-trifluoromethyl-phenyl)-ethylam...)
Affinity DataKi:  35nMAssay Description:For all experiments, serotonin (5-HT) hydrochloride was used as a positive control, and an appropriate high affinity, cold ligand (e.g., mianserin hy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent

Target5-hydroxytryptamine receptor 1A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50038369(2-(2,5-Dimethoxy-4-trifluoromethyl-phenyl)-ethylam...)
Affinity DataKi:  3.42E+3nMAssay Description:Tested for the binding affinity against the site labelled by the 5-hydroxytryptamine 1A receptor agonist [3H]- 8-OH-DPATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed