BDBM50039197 1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-yl-ethyl ester::CHEMBL305881

SMILES c1ccc(cc1)C2(CCCCC2)C(=O)OCCN3CCOCC3

InChI Key InChIKey=RQHKZUBCUZVZEF-UHFFFAOYSA-N

Data  12 KI  2 IC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50039197   

TargetSigma non-opioid intracellular receptor 1(Human)
Aligarh Muslim University

Curated by ChEMBL
LigandPNGBDBM50039197(1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to SIGMAR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039197(1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-...)
Affinity DataKi:  44nMAssay Description:Tested for its binding affinity towards sigma-1 site in rat brain, using [3H]-(+)-SKF- 10047 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50039197(1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-...)
Affinity DataIC50: 44nMAssay Description:Inhibition of [3H]NANM binding to sigma receptor obtained from tissue homogenate preparation of fresh whole rat brain minus cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Aligarh Muslim University

Curated by ChEMBL
LigandPNGBDBM50039197(1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-...)
Affinity DataKi:  46.5nMAssay Description:Binding affinity against Sigma receptor type 1 was determined by the displacement of [3H]pentazocine radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Aligarh Muslim University

Curated by ChEMBL
LigandPNGBDBM50039197(1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-...)
Affinity DataKi:  53nMAssay Description:Binding affinity to human sigma 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50039197(1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-...)
Affinity DataKi:  59nMAssay Description:Displacement of [3H]-PTZ from sigma1 receptor in guinea pig brain membranes after 150 mins in presence of 1 mM DPH by liquid scintillation counting m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2019
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50039197(1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-...)
Affinity DataKi:  67nMAssay Description:Displacement of [3H]-PTZ from sigma1 receptor in guinea pig brain membranes after 150 mins in presence of 250 uM DPH by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2019
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50039197(1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-...)
Affinity DataKi:  151nMAssay Description:Displacement of [3H]-PTZ from sigma1 receptor in guinea pig brain membranes after 150 mins in presence of 1 mM DPH by liquid scintillation counting m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2019
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50039197(1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-...)
Affinity DataKi: >4.00E+3nMAssay Description:Binding affinity to delta opioid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2019
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50039197(1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-...)
Affinity DataKi: >4.00E+3nMAssay Description:Binding affinity to kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2019
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Nida-Irp

Curated by ChEMBL
LigandPNGBDBM50039197(1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-...)
Affinity DataKi:  5.34E+3nMAssay Description:Binding affinity against dopamine transporter was determined by the displacement of [3H]WIN-35428 radioligand in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Nida-Irp

Curated by ChEMBL
LigandPNGBDBM50039197(1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-...)
Affinity DataKi:  5.37E+3nMAssay Description:Binding affinity to dopamine transporter (DAT) using [3H]WIN-35428 as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50039197(1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-...)
Affinity DataKi:  3.21E+4nMAssay Description:Binding affinity to human sigma 2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysosomal Pro-X carboxypeptidase(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50039197(1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of binding to PCP receptor obtained from tissue homogenate preparation of fresh whole rat brain minus cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed