BDBM50043002 CHEMBL3355015

SMILES Nc1ncnc(N2CCC[C@H]2c2nc3cccc(Cl)c3c(=O)n2-c2cccnc2)c1C#N

InChI Key InChIKey=ZFWDHORKWLHUCN-UHFFFAOYSA-N

Data  6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50043002   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043002(CHEMBL3355015)Copy SMILESCopy InChI

Affinity DataIC50: 14nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as PI3Kalpha-mediated Akt1/2 (S473) phosphorylation rate by cellular assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043002(CHEMBL3355015)Copy SMILESCopy InChI

Affinity DataIC50: 14nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043002(CHEMBL3355015)Copy SMILESCopy InChI

Affinity DataIC50: 150nMAssay Description:Inhibition of PI3Kgamma (unknown origin) assessed as PI3Kalpha-mediated Akt1/2 (S473) phosphorylation rate by cellular assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043002(CHEMBL3355015)Copy SMILESCopy InChI

Affinity DataIC50: 150nMAssay Description:Inhibition of PI3Kgamma (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043002(CHEMBL3355015)Copy SMILESCopy InChI

Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) assessed as PI3Kalpha-mediated Akt1/2 (S473) phosphorylation rate by cellular assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043002(CHEMBL3355015)Copy SMILESCopy InChI

Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL