BDBM50043003 CHEMBL3355016

SMILES Nc1ncnc(N2CCC[C@H]2c2nc3cccc(Cl)c3c(=O)n2N2CCOCC2)c1C#N

InChI Key InChIKey=DZGDXPLNVGCLRY-UHFFFAOYSA-N

Data  6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50043003   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043003(CHEMBL3355016)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as PI3Kalpha-mediated Akt1/2 (S473) phosphorylation rate by cellular assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043003(CHEMBL3355016)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043003(CHEMBL3355016)Copy SMILESCopy InChI

Affinity DataIC50: 200nMAssay Description:Inhibition of PI3Kgamma (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043003(CHEMBL3355016)Copy SMILESCopy InChI

Affinity DataIC50: 200nMAssay Description:Inhibition of PI3Kgamma (unknown origin) assessed as PI3Kalpha-mediated Akt1/2 (S473) phosphorylation rate by cellular assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043003(CHEMBL3355016)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) assessed as PI3Kalpha-mediated Akt1/2 (S473) phosphorylation rate by cellular assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043003(CHEMBL3355016)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL