BDBM50043286 CHEMBL3355040

SMILES COc1cc2ncnc(Nc3ccc4N(CCc4c3)C(=O)Cc3c(C)[nH]c4c(F)cccc34)c2cc1OC

InChI Key InChIKey=AWUXQHUKDCFMQB-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50043286   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043286(CHEMBL3355040)Copy SMILESCopy InChI

Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant GST-tagged PERK (unknown origin) by LanthaScreen assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy BDB DOIPubMed
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TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043286(CHEMBL3355040)Copy SMILESCopy InChI

Affinity DataIC50: 40nMAssay Description:Inhibition of PERK (unknown origin) expressed in HEK293 cells assessed as inhibition of phosphorylation of GFP-eIF2 alpha by cell-based TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL