BDBM50043623 CHEMBL3355491

SMILES CN(Cc1ccccc1)C(=O)c1ccc(cc1)S(=O)(=O)Nc1cccc(C)c1

InChI Key InChIKey=FYTAJCOXVSKAQF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50043623   

TargetLIM domain kinase 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043623(CHEMBL3355491)
Affinity DataIC50: 22nMAssay Description:Inhibition of human full-length LIMK2 expressed in Sf9 cells assessed as incorporation of [33P] from ATP into biotinylated-cofilin substrate in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043623(CHEMBL3355491)
Affinity DataIC50: 200nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043623(CHEMBL3355491)
Affinity DataIC50: 269nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50043623(CHEMBL3355491)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50043623(CHEMBL3355491)
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed