BDBM50043658 CHEMBL3355553::US9416132, 8-57

SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1

InChI Key InChIKey=OQJHUFMYQSOHFU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50043658   

TargetSerine/threonine-protein kinase pim-1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043658(CHEMBL3355553 | US9416132, 8-57)
Affinity DataIC50: 66nMAssay Description:Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043658(CHEMBL3355553 | US9416132, 8-57)
Affinity DataIC50: 66nMT: 2°CAssay Description:These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043658(CHEMBL3355553 | US9416132, 8-57)
Affinity DataIC50: 4.66E+3nMAssay Description:Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed