BDBM50043691 CHEMBL3355543::US10047093, 8-53::US10392392, Example 8-53::US10875864, EX. 8-53::US9416132, 8-53

SMILES N[C@H]1CCCN(C1)c1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1

InChI Key InChIKey=PHNMDUIFDUSSMV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50043691   

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043691(US10047093, 8-53 | CHEMBL3355543 | US9416132, 8-53...)
Affinity DataIC50: 132nMT: 2°CAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043691(US10047093, 8-53 | CHEMBL3355543 | US9416132, 8-53...)
Affinity DataIC50: 132nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043691(US10047093, 8-53 | CHEMBL3355543 | US9416132, 8-53...)
Affinity DataIC50: 132nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043691(US10047093, 8-53 | CHEMBL3355543 | US9416132, 8-53...)
Affinity DataIC50: 132nMT: 2°CAssay Description:These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043691(US10047093, 8-53 | CHEMBL3355543 | US9416132, 8-53...)
Affinity DataIC50: 132nMAssay Description:Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043691(US10047093, 8-53 | CHEMBL3355543 | US9416132, 8-53...)
Affinity DataIC50: 987nMAssay Description:Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed