BDBM50043700 CHEMBL3355560::US10047093, 8-62::US10392392, Example 8-62::US10875864, EX. 8-62::US9416132, 8-62

SMILES C[C@]1(O)CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1

InChI Key InChIKey=HQBDNWLHCUWEJY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50043700   

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043700(US10047093, 8-62 | CHEMBL3355560 | US9416132, 8-62...)
Affinity DataIC50: 378nMT: 2°CAssay Description:These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043700(US10047093, 8-62 | CHEMBL3355560 | US9416132, 8-62...)
Affinity DataIC50: 378nMT: 2°CAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043700(US10047093, 8-62 | CHEMBL3355560 | US9416132, 8-62...)
Affinity DataIC50: 378nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043700(US10047093, 8-62 | CHEMBL3355560 | US9416132, 8-62...)
Affinity DataIC50: 378nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043700(US10047093, 8-62 | CHEMBL3355560 | US9416132, 8-62...)
Affinity DataIC50: 378nMAssay Description:Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043700(US10047093, 8-62 | CHEMBL3355560 | US9416132, 8-62...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed