BDBM50043917 CHEMBL3356042::US9174993, 63

SMILES Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2cccc(F)c2Cl)cc1

InChI Key InChIKey=OXRXVDTXSUMUQL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50043917   

TargetSerine/threonine-protein kinase Sgk1(Human)
Sanofi R & D

Curated by ChEMBL
LigandPNGBDBM50043917(US9174993, 63 | CHEMBL3356042)
Affinity DataIC50: 21nMAssay Description:Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Sanofi R & D

Curated by ChEMBL
LigandPNGBDBM50043917(US9174993, 63 | CHEMBL3356042)
Affinity DataIC50: 21nMAssay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetSerine/threonine-protein kinase Sgk1(Human)
Sanofi R & D

Curated by ChEMBL
LigandPNGBDBM50043917(US9174993, 63 | CHEMBL3356042)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed