BDBM50046740 CHEMBL1939972::US9186360, 90

SMILES COCCCOc1cccc(c1)C1NC(=S)NC2=C1C(=O)c1ccccc21

InChI Key InChIKey=DTVXBNDIMDRBBV-UHFFFAOYSA-N

Data  7 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50046740   

TargetTransient receptor potential cation channel subfamily A member 1(Human)
Glenmark Pharmaceuticals

US Patent
LigandPNGBDBM50046740(CHEMBL1939972 | US9186360, 90)
Affinity DataIC50: 5.61nMT: 2°CAssay Description:The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

LigandPNGBDBM50046740(CHEMBL1939972 | US9186360, 90)
Affinity DataIC50: 28nMAssay Description:Antagonist activity at rat TRPA1 assessed as inhibition of AITC-induced calcium uptake by [45Ca2+] fluorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Glenmark Pharmaceuticals

US Patent
LigandPNGBDBM50046740(CHEMBL1939972 | US9186360, 90)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at human TRPA1 assessed as inhibition of AITC-induced calcium uptake by [45Ca2+] fluorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Glenmark Pharmaceuticals

US Patent
LigandPNGBDBM50046740(CHEMBL1939972 | US9186360, 90)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Radiometric calcium assay was performed as described above with some minor modifications. Assay was carried out in total volume of 200 μl at 30&de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Glenmark Pharmaceuticals

US Patent
LigandPNGBDBM50046740(CHEMBL1939972 | US9186360, 90)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Radiometric calcium assay was performed as described above with some minor modifications. Assay was carried out in total volume of 200 μl at 30&de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

TargetTransient receptor potential cation channel subfamily V member 3(Human)
Glenmark Pharmaceuticals

US Patent
LigandPNGBDBM50046740(CHEMBL1939972 | US9186360, 90)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Radiometric calcium assay was performed as described above with some minor modifications. Assay was carried out in total volume of 200 μl at 30&de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glenmark Pharmaceuticals

US Patent
LigandPNGBDBM50046740(CHEMBL1939972 | US9186360, 90)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Radiometric calcium assay was performed as described above with some minor modifications. Assay was carried out in total volume of 200 μl at 30&de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

LigandPNGBDBM50046740(CHEMBL1939972 | US9186360, 90)
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at rat TRPA1 by [45Ca2+] fluorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Glenmark Pharmaceuticals

US Patent
LigandPNGBDBM50046740(CHEMBL1939972 | US9186360, 90)
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at human TRPA1 by [45Ca2+] fluorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed