BDBM50048774 (R)-2-{[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoyl]-methyl-amino}-3-(1H-indol-3-yl)-propionic acid::CHEMBL283276

SMILES CN([C@H](Cc1c[nH]c2ccccc12)C(O)=O)C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1

InChI Key InChIKey=IYPQGGAZCDEUJO-PLYLYKGUSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50048774   

TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Rotta Research Laboratorium

Curated by ChEMBL
LigandPNGBDBM50048774((R)-2-{[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichlo...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(RAT)
Rotta Research Laboratorium

Curated by ChEMBL
LigandPNGBDBM50048774((R)-2-{[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichlo...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of [125I]CCK-8 binding to Cholecystokinin type A receptor in rat pancreasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Rotta Research Laboratorium

Curated by ChEMBL
LigandPNGBDBM50048774((R)-2-{[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichlo...)
Affinity DataIC50:  57nMAssay Description:Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed