BDBM50048891 (3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-one::CHEMBL61636::US12565495, Example TBZ

SMILES CC(C)C[C@@H]1CN2CCc3cc(c(cc3[C@H]2CC1=O)OC)OC

InChI Key InChIKey=MKJIEFSOBYUXJB-UHFFFAOYSA-N

Data  2 KI  1 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50048891   

TargetSynaptic vesicular amine transporter(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50048891BDBM50048891((3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-...)
Affinity DataKi:  4.47nMAssay Description:Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50048891BDBM50048891((3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-...)
Affinity DataKi:  8.10nMAssay Description:In vitro inhibition of [3H]- Methoxytetrabenazine binding to rat brain vesicular monoamine transporter 2 (VMAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50048891BDBM50048891((3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-...)
Affinity DataIC50: 23nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2026
Entry Details
US Patent
PDB3D3D Structure (crystal)