BDBM50049500 1-Nitro-4-(4,6,6-trimethyl-2-methylene-cyclohex-3-enylsulfanyl)-benzene::CHEMBL49754

SMILES CC1=CC(=C)C(Sc2ccc(cc2)[N+]([O-])=O)C(C)(C)C1

InChI Key InChIKey=XFNLFWZVHZGCOI-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50049500   

TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049500(1-Nitro-4-(4,6,6-trimethyl-2-methylene-cyclohex-3-...)
Affinity DataKi:  119nMAssay Description:Binding affinity determined for human Progesterone receptor A isoformMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049500(1-Nitro-4-(4,6,6-trimethyl-2-methylene-cyclohex-3-...)
Affinity DataKi:  8.22E+3nMAssay Description:Binding affinity was determined for human glucocorticoid receptor(hGR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049500(1-Nitro-4-(4,6,6-trimethyl-2-methylene-cyclohex-3-...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity determined against human Androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049500(1-Nitro-4-(4,6,6-trimethyl-2-methylene-cyclohex-3-...)
Affinity DataIC50:  420nMAssay Description:Antagonistic potency to the human progesterone receptor measured in the T-47D alkaline phosphatase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049500(1-Nitro-4-(4,6,6-trimethyl-2-methylene-cyclohex-3-...)
Affinity DataIC50:  1.35E+3nMAssay Description:Concentration required to give half-maximal inhibition against human Progesterone receptor B isoform in co-transfected CV-1 cell lines.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed