BDBM50050425 6-(3,4-Dimethoxy-phenylsulfanylmethyl)-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL23244

SMILES COc1ccc(SCc2cnc3nc(N)nc(N)c3c2C)cc1OC

InChI Key InChIKey=XQDLKIMOHMTKTI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50050425   

TargetDihydrofolate reductase(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50050425(6-(3,4-Dimethoxy-phenylsulfanylmethyl)-5-methyl-py...)
Affinity DataIC50: 1.5nMAssay Description:Antimycobacterial activity against Mycobacterium avium complex dihydrofolate reductase (MAC DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050425(6-(3,4-Dimethoxy-phenylsulfanylmethyl)-5-methyl-py...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050425(6-(3,4-Dimethoxy-phenylsulfanylmethyl)-5-methyl-py...)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050425(6-(3,4-Dimethoxy-phenylsulfanylmethyl)-5-methyl-py...)
Affinity DataIC50: 180nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50050425(6-(3,4-Dimethoxy-phenylsulfanylmethyl)-5-methyl-py...)
Affinity DataIC50: 440nMAssay Description:Antimycobacterial activity against human dihydrofolate reductase (hDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed