BDBM50050917 CHEMBL42539::[2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3-p-tolyl-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-amine

SMILES COc1cccc(OC)c1OCCNCC1Oc2ccccc2OC1c1ccc(C)cc1

InChI Key InChIKey=UNHGFWKSHHCRHF-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50050917   

TargetAlpha-1A adrenergic receptor(Bovine)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50050917([2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3-p-tolyl-2,3-d...)
Affinity DataKi:  0.910nMAssay Description:Binding affinity towards Alpha-1A adrenergic receptor in bovine brain using [3H]-prazosin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50050917([2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3-p-tolyl-2,3-d...)
Affinity DataKi:  4.10nMAssay Description:Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately activeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50050917([2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3-p-tolyl-2,3-d...)
Affinity DataKi:  5.32nMAssay Description:Binding affinity towards Alpha-1A adrenergic receptor in rat hippocampus (+ 10 uM) CES membrane using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50050917([2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3-p-tolyl-2,3-d...)
Affinity DataKi:  11.8nMAssay Description:Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50050917([2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3-p-tolyl-2,3-d...)
Affinity DataKi:  51.4nMAssay Description:Binding affinity towards Alpha-1B adrenergic receptor hamster smooth muscle using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50050917([2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3-p-tolyl-2,3-d...)
Affinity DataKi:  82.3nMAssay Description:In vitro inhibitory activity against [3H]raclopride binding to Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50050917([2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3-p-tolyl-2,3-d...)
Affinity DataKi:  103nMAssay Description:Binding affinity towards Alpha-1B adrenergic receptor in rat liver using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50050917([2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3-p-tolyl-2,3-d...)
Affinity DataKi:  606nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hypocampus membrane using [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed