BDBM50052180 CHEMBL328866::N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-chloro-4-(cyclopropanecarbonyl-amino)-2-methoxy-benzamide

SMILES COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1

InChI Key InChIKey=CPVZPPFHQBIJNB-UHFFFAOYSA-N

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50052180   

TargetD(4) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052180(N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-chloro-4-(cyclo...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052180(N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-chloro-4-(cyclo...)
Affinity DataKi:  21nMAssay Description:Binding affinity to rat Dopamine receptor D3 expressed in CHO cells was determined using [125 I] iodosulpride as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052180(N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-chloro-4-(cyclo...)
Affinity DataKi:  220nMAssay Description:Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Mouse)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052180(N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-chloro-4-(cyclo...)
Affinity DataKi:  4.00E+3nMAssay Description:Compound was tested for the Binding affinity against N1e-115 neuroblastoma 5-hydroxytryptamine 3 receptor by Radio ligand [3H]GR-65630 binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052180(N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-chloro-4-(cyclo...)
Affinity DataKi:  5.40E+3nMAssay Description:Compound was tested for the Binding affinity against rat cortical Muscarinic acetylcholine receptor M1 by Radio ligand [3H]pirenzepine binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052180(N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-chloro-4-(cyclo...)
Affinity DataKi:  7.30E+3nMAssay Description:Compound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052180(N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-chloro-4-(cyclo...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for the Binding affinity against rat cortical H1 receptor by Radio ligand [3H]pyrilamine binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052180(N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-chloro-4-(cyclo...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for the Binding affinity against rat frontal cortex 5-hydroxytryptamine 2A receptor by Radio ligand [3H]ketanserin binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052180(N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-chloro-4-(cyclo...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for the Binding affinity against rat hippocampal 5-hydroxytryptamine 1A receptor by Radio ligand [3H]8-OH-DPAT binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052180(N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-chloro-4-(cyclo...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052180(N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-chloro-4-(cyclo...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed