BDBM50054761 CHEMBL143767::Trifluoro-methanesulfonic acid 3-(2-dimethylamino-ethyl)-1H-indol-5-yl ester

SMILES CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12

InChI Key InChIKey=HWRKZNBGZMBBTP-UHFFFAOYSA-N

Data  6 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50054761   

Target5-hydroxytryptamine receptor 1D(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50054761(Trifluoro-methanesulfonic acid 3-(2-dimethylamino-...)
Affinity DataKi:  3.20nMAssay Description:Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50054761(Trifluoro-methanesulfonic acid 3-(2-dimethylamino-...)
Affinity DataIC50: 8.40nMAssay Description:Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50054761(Trifluoro-methanesulfonic acid 3-(2-dimethylamino-...)
Affinity DataKi:  28nMAssay Description:Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor beta measured as the reduction of forskolin-stimulated cAMP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50054761(Trifluoro-methanesulfonic acid 3-(2-dimethylamino-...)
Affinity DataKi:  30nMAssay Description:Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50054761(Trifluoro-methanesulfonic acid 3-(2-dimethylamino-...)
Affinity DataKi:  32nMAssay Description:Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor beta expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50054761(Trifluoro-methanesulfonic acid 3-(2-dimethylamino-...)
Affinity DataKi:  40nMAssay Description:Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1A receptor expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50054761(Trifluoro-methanesulfonic acid 3-(2-dimethylamino-...)
Affinity DataIC50: 98nMAssay Description:Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor beta clones expressed in human embryonic kidney (HEK 293) cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50054761(Trifluoro-methanesulfonic acid 3-(2-dimethylamino-...)
Affinity DataKi:  538nMAssay Description:Binding affinity for rat dopamine D2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed