BDBM50055967 CHEMBL3325714

SMILES Cc1nn(c2CC(C)(C)CC(=O)c12)-c1ccc(Br)cc1Br

InChI Key InChIKey=IXQVTUGHVSDDBK-UHFFFAOYSA-N

Data  1 KI  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50055967   

TargetMu-type opioid receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50055967(CHEMBL3325714)
Affinity DataEC50:  41nMAssay Description:Agonist activity at human mu opioid receptor expressed CHO-K1 cells coexpressing Galpha15 assessed as induction of intracellular calcium release by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50055967(CHEMBL3325714)
Affinity DataIC50: 410nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50055967(CHEMBL3325714)
Affinity DataKi:  470nMAssay Description:Displacement of [3H]-naloxone from rat mu opioid receptor expressed in HEK cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50055967(CHEMBL3325714)
Affinity DataIC50: 730nMAssay Description:Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production after 30 mins by H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50055967(CHEMBL3325714)
Affinity DataIC50: 1.69E+3nMAssay Description:Agonist activity at human delta opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50055967(CHEMBL3325714)
Affinity DataEC50:  5.49E+3nMAssay Description:Agonist activity at myc-tagged mu opioid receptor (unknown origin) expressed in AtT-20 cells assessed as induction of membrane potential hyperpolariz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed