BDBM50056199 CHEMBL3329684

SMILES COc1ccc(C(=O)NC(=O)Nc2ccc3\C(=C\c4[nH]c(C)c(C(=O)NCCN5CCCC5)c4C)C(=O)Nc3c2)c(F)c1

InChI Key InChIKey=NKKNQMFHKZEGQU-KQWNVCNZSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50056199   

TargetAurora kinase B(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Aurora B (unknown origin) using HLRRASLG substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50:  14nMAssay Description:Inhibition of c-Kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin) using 3-cyano-7-ethoxycoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) using Vivid OOMR substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))TBA
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Aurora-A (unknown origin) by kinase-glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) using 3-cyano-7-ethoxycoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using Vivid OOMR substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50:  9.67E+3nMAssay Description:Inhibition of human ERG channel after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of FLT3 (unknown origin) using EAIYAAPFAKKK substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin) using 3-cyano-7-ethoxycoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed