BDBM50056427 CHEMBL3326909

SMILES Cc1cc2c(NC(=O)N[C@@H]3CC(CF)(CF)Oc4c(F)cccc34)cccc2cn1

InChI Key InChIKey=QTDRSEIGXUBECZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50056427   

LigandPNGBDBM50056427(CHEMBL3326909)
Affinity DataIC50: 22nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50056427(CHEMBL3326909)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50056427(CHEMBL3326909)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 7-benzyloxyquiniline substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed