BDBM50056568 1-(benzo[b]thiophen-2-ylmethyl)-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperazine::1-Benzo[b]thiophen-2-ylmethyl-4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazine::CHEMBL159445

SMILES Fc1ccc(cc1)C(OCCN1CCN(Cc2cc3ccccc3s2)CC1)c1ccc(F)cc1

InChI Key InChIKey=JGDQTUYVDMVTLR-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50056568   

TargetSodium-dependent dopamine transporter(Rat)
University Heights

Curated by ChEMBL
LigandPNGBDBM50056568(1-Benzo[b]thiophen-2-ylmethyl-4-{2-[bis-(4-fluoro-...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [125I]RTI55 from DAT in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University Heights

Curated by ChEMBL
LigandPNGBDBM50056568(1-Benzo[b]thiophen-2-ylmethyl-4-{2-[bis-(4-fluoro-...)
Affinity DataIC50: 4.10nMAssay Description:Binding affinity at the dopamine transporter using [125I]RTI-55 in rat caudate membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University Heights

Curated by ChEMBL
LigandPNGBDBM50056568(1-Benzo[b]thiophen-2-ylmethyl-4-{2-[bis-(4-fluoro-...)
Affinity DataIC50: 34nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]dopamine on synaptosomes obtained from rat caudate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University Heights

Curated by ChEMBL
LigandPNGBDBM50056568(1-Benzo[b]thiophen-2-ylmethyl-4-{2-[bis-(4-fluoro-...)
Affinity DataKi:  495nMAssay Description:Displacement of [125I]RTI55 from SERT in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University Heights

Curated by ChEMBL
LigandPNGBDBM50056568(1-Benzo[b]thiophen-2-ylmethyl-4-{2-[bis-(4-fluoro-...)
Affinity DataIC50: 495nMAssay Description:Binding affinity at the serotonin transporter using [125I]RTI-55 in rat caudate membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University Heights

Curated by ChEMBL
LigandPNGBDBM50056568(1-Benzo[b]thiophen-2-ylmethyl-4-{2-[bis-(4-fluoro-...)
Affinity DataIC50: 1.23E+3nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed