BDBM50056577 3-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperazin-1-yl)methyl)quinoline::3-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-ylmethyl)-quinoline::CHEMBL164297

SMILES Fc1ccc(cc1)C(OCCN1CCN(Cc2cnc3ccccc3c2)CC1)c1ccc(F)cc1

InChI Key InChIKey=XBTOAXDXEWFSSU-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50056577   

TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056577(3-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperaz...)
Affinity DataIC50: 16nMAssay Description:Binding affinity at the dopamine transporter using [125I]RTI-55 in rat caudate membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056577(3-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperaz...)
Affinity DataKi:  16.1nMAssay Description:Displacement of [125I]RTI55 from DAT in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056577(3-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperaz...)
Affinity DataIC50: 74nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]dopamine on synaptosomes obtained from rat caudate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056577(3-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperaz...)
Affinity DataIC50: 485nMAssay Description:Binding affinity at the serotonin transporter using [125I]RTI-55 in rat caudate membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056577(3-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperaz...)
Affinity DataKi:  485nMAssay Description:Displacement of [125I]RTI55 from SERT in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056577(3-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperaz...)
Affinity DataIC50: 851nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed