BDBM50056578 2-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperazin-1-yl)methyl)quinoline::2-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-ylmethyl)-quinoline::CHEMBL434093

SMILES Fc1ccc(cc1)C(OCCN1CCN(Cc2ccc3ccccc3n2)CC1)c1ccc(F)cc1

InChI Key InChIKey=UZULFJXPKRYCSG-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50056578   

TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056578(2-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperaz...)
Affinity DataIC50: 51nMAssay Description:Binding affinity at the serotonin transporter using [125I]RTI-55 in rat caudate membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056578(2-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperaz...)
Affinity DataKi:  51nMAssay Description:Displacement of [125I]RTI55 from SERT in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University Heights

Curated by ChEMBL
LigandPNGBDBM50056578(2-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperaz...)
Affinity DataKi:  56nMAssay Description:Displacement of [125I]RTI55 from DAT in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University Heights

Curated by ChEMBL
LigandPNGBDBM50056578(2-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperaz...)
Affinity DataIC50: 56nMAssay Description:Binding affinity at the dopamine transporter using [125I]RTI-55 in rat caudate membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University Heights

Curated by ChEMBL
LigandPNGBDBM50056578(2-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperaz...)
Affinity DataIC50: 106nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]dopamine on synaptosomes obtained from rat caudate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University Heights

Curated by ChEMBL
LigandPNGBDBM50056578(2-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperaz...)
Affinity DataIC50: 339nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed