BDBM50057962 4-[2-(3-Chloro-4-methylsulfanyl-phenyl)-4-trifluoromethyl-imidazol-1-yl]-benzenesulfonamide::CHEMBL42674

SMILES CSc1ccc(cc1Cl)-c1nc(cn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F

InChI Key InChIKey=UATKBDIWWOKIJQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50057962   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057962(4-[2-(3-Chloro-4-methylsulfanyl-phenyl)-4-trifluor...)
Affinity DataIC50:  3.54E+3nMAssay Description:Concentration required to inhibit human prostaglandin G/H synthase 1 (COX-1) by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50057962(4-[2-(3-Chloro-4-methylsulfanyl-phenyl)-4-trifluor...)
Affinity DataIC50:  9.99E+6nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50057962(4-[2-(3-Chloro-4-methylsulfanyl-phenyl)-4-trifluor...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50057962(4-[2-(3-Chloro-4-methylsulfanyl-phenyl)-4-trifluor...)
Affinity DataIC50:  10nMAssay Description:Concentration required to inhibit human Prostaglandin G/H synthase 2 (COX-2) by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed