BDBM50059281 CHEMBL3393444::US9156845, 6

SMILES C[C@H]1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

InChI Key InChIKey=PFFIEMXZEROLOA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50059281   

LigandPNGBDBM50059281(CHEMBL3393444 | US9156845, 6)
Affinity DataIC50: 7nMpH: 7.5Assay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2016
Entry Details
US Patent

LigandPNGBDBM50059281(CHEMBL3393444 | US9156845, 6)
Affinity DataIC50: 7nMAssay Description:Inhibition of GST-tagged truncated human recombinant LRRK2 using fluorescein-labeled LRRKtide peptide substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50059281(CHEMBL3393444 | US9156845, 6)
Affinity DataIC50: 37nMpH: 7.5Assay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2016
Entry Details
US Patent

LigandPNGBDBM50059281(CHEMBL3393444 | US9156845, 6)
Affinity DataIC50: 122nMAssay Description:Inhibition of full length LRRK2 (unknown origin) expressed in HEK293 cells assessed as reduction in S935 phosphorylation incubated for 90 mins by ELI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50059281(CHEMBL3393444 | US9156845, 6)
Affinity DataIC50: 179nMAssay Description:Inhibition of human recombinant MST2 using Ser/Thr peptide 7 substrate after 45 mins by Z-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 26(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50059281(CHEMBL3393444 | US9156845, 6)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant MST4 using Ser/Thr peptide 7 substrate after 60 mins by Z-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed