BDBM500599 4-(1-methyl-1H- pyrrolo[2,3- b]pyridin-4- yl)-7-((5- (piperazin-1- yl)pyridin-2- yl)amino)-2,3- dihydro-1H- pyrrolo[3,4- c]pyridin-1-one::US11021481, Compound I-258::US11021481, Compound I-266::US11078201, Compound I-258::US11548890, Compound I-258

SMILES Cn1ccc2c(ccnc12)-c1ncc(Nc2ccc(cn2)N2CCNCC2)c2C(=O)NCc12

InChI Key InChIKey=GFGFCJMNYJDQNT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 500599   

LigandPNGBDBM500599(4-(1-methyl-1H- pyrrolo[2,3- b]pyridin-4- yl)-7-((...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500599(4-(1-methyl-1H- pyrrolo[2,3- b]pyridin-4- yl)-7-((...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500599(4-(1-methyl-1H- pyrrolo[2,3- b]pyridin-4- yl)-7-((...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500599(4-(1-methyl-1H- pyrrolo[2,3- b]pyridin-4- yl)-7-((...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500599(4-(1-methyl-1H- pyrrolo[2,3- b]pyridin-4- yl)-7-((...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500599(4-(1-methyl-1H- pyrrolo[2,3- b]pyridin-4- yl)-7-((...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent