BDBM500600 (R)-4-(6- methyl-6,7- dihydro-5H- pyrazolo[5,1- b][1,3]oxazin- 3-yl)-7-((5-(4- methylpiperazin- 1-yl)pyridin-2- yl)amino)isoin- dolin-1-one::US11021481, Compound I-259::US11021481, Compound I-261::US11078201, Compound I-261::US11548890, Compound I-261

SMILES C[C@@H]1COc2c(cnn2C1)-c1ccc(Nc2ccc(cn2)N2CCN(C)CC2)c2C(=O)NCc12

InChI Key InChIKey=ALWRRZLUFQJHJF-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 500600   

LigandPNGBDBM500600(US11021481, Compound I-261 | (R)-4-(6- methyl-6,7-...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500600(US11021481, Compound I-261 | (R)-4-(6- methyl-6,7-...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500600(US11021481, Compound I-261 | (R)-4-(6- methyl-6,7-...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500600(US11021481, Compound I-261 | (R)-4-(6- methyl-6,7-...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500600(US11021481, Compound I-261 | (R)-4-(6- methyl-6,7-...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500600(US11021481, Compound I-261 | (R)-4-(6- methyl-6,7-...)
Affinity DataIC50: 300nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500600(US11021481, Compound I-261 | (R)-4-(6- methyl-6,7-...)
Affinity DataIC50: 550nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500600(US11021481, Compound I-261 | (R)-4-(6- methyl-6,7-...)
Affinity DataIC50: 550nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500600(US11021481, Compound I-261 | (R)-4-(6- methyl-6,7-...)
Affinity DataIC50: 550nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500600(US11021481, Compound I-261 | (R)-4-(6- methyl-6,7-...)
Affinity DataIC50: 550nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent