BDBM500604 (FR)-4-(5-mFethyl- 4,5A,6,7- tetrahydropyra- zolo[1,5- a]pyridin-3- yl)-7-((5-(4- methylpiperazin- 1-yl)pyridin-2- yl)amino)isoin- dolin-1-one::US11021481, Compound I-263::US11078201, Compound I-263::US11548890, Compound I-263

SMILES C[C@@H]1CCn2ncc(c2C1)-c1ccc(Nc2ccc(cn2)N2CCN(C)CC2)c2C(=O)NCc12

InChI Key InChIKey=CDEKHHSOSDYKQI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500604   

LigandPNGBDBM500604(US11021481, Compound I-263 | (FR)-4-(5-mFethyl- 4,...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500604(US11021481, Compound I-263 | (FR)-4-(5-mFethyl- 4,...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500604(US11021481, Compound I-263 | (FR)-4-(5-mFethyl- 4,...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500604(US11021481, Compound I-263 | (FR)-4-(5-mFethyl- 4,...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500604(US11021481, Compound I-263 | (FR)-4-(5-mFethyl- 4,...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent