BDBM500615 7-((5-(4- hydroxy-1- methylpiperidin- 4-yl)pyridin- 2-yl)amino)-4- (1-methyl-1H- pyrrolo[2,3- b]pyridin-4- yl)isoindolin- 1-one::US11021481, Compound I-274::US11078201, Compound I-274::US11548890, Compound I-274

SMILES CN1CCC(O)(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)nc1

InChI Key InChIKey=IKQCEQHXWSXFBH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500615   

LigandPNGBDBM500615(US11021481, Compound I-274 | 7-((5-(4- hydroxy-1- ...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500615(US11021481, Compound I-274 | 7-((5-(4- hydroxy-1- ...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500615(US11021481, Compound I-274 | 7-((5-(4- hydroxy-1- ...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500615(US11021481, Compound I-274 | 7-((5-(4- hydroxy-1- ...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500615(US11021481, Compound I-274 | 7-((5-(4- hydroxy-1- ...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent