BDBM50061916 3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benzenesulfonamide::CHEMBL134915
SMILES COc1ccc(cc1OC)S(=O)(=O)Nc1nc(cs1)-c1cccc(c1)[N+]([O-])=O
InChI Key InChIKey=NDPBMCKQJOZAQX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50061916
Affinity DataKi: 4.80nMAssay Description:Inhibitory constant of the compound against Kynurenine 3-hydroxylaseMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of C57BL/6J mouse KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS a...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of Wistar rat KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analy...More data for this Ligand-Target Pair
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Chdi Management/Chdi Foundation
Curated by ChEMBL
Chdi Management/Chdi Foundation
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of human KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Chdi Management/Chdi Foundation
Curated by ChEMBL
Chdi Management/Chdi Foundation
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of Phosphodiesterase 2 from pig coronary arteryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of C57BL/6J mouse KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS a...More data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Wistar rat KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analy...More data for this Ligand-Target Pair
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Chdi Management/Chdi Foundation
Curated by ChEMBL
Chdi Management/Chdi Foundation
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human KMOMore data for this Ligand-Target Pair
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Chdi Management/Chdi Foundation
Curated by ChEMBL
Chdi Management/Chdi Foundation
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of KMO (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Chdi Management/Chdi Foundation
Curated by ChEMBL
Chdi Management/Chdi Foundation
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analysis i...More data for this Ligand-Target Pair