BDBM500631 7-((5-(4- hydroxy-4- (morpholino- methyl)piperi- din-1-yl)pyridin- 2-yl)amino)-4- (1-methyl-1H- pyrrolo[2,3- b]pyridin-4- yl)isoindolin- 1-one::US11021481, Compound I-291::US11078201, Compound I-291::US11548890, Compound I-291

SMILES Cn1ccc2c(ccnc12)-c1ccc(Nc2ccc(cn2)N2CCC(O)(CN3CCOCC3)CC2)c2C(=O)NCc12

InChI Key InChIKey=QAFVYUNNSDYMCF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500631   

LigandPNGBDBM500631(US11021481, Compound I-291 | 7-((5-(4- hydroxy-4- ...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500631(US11021481, Compound I-291 | 7-((5-(4- hydroxy-4- ...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500631(US11021481, Compound I-291 | 7-((5-(4- hydroxy-4- ...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500631(US11021481, Compound I-291 | 7-((5-(4- hydroxy-4- ...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500631(US11021481, Compound I-291 | 7-((5-(4- hydroxy-4- ...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent