BDBM500634 6-methyl-2- ((7-(1-methyl- 1H-pyrrolo[2,3- b]pyridin-4- yl)-3-oxoisoindolin- 4-yl)amino)- 5.6-dihydro- 4H-pyrazolo[1,5- d][l,4]diaze- pin-7(8H)-one::US11021481, Compound I-294::US11078201, Compound I-294::US11548890, Compound I-294

SMILES CN1CCc2cc(Nc3ccc(c4CNC(=O)c34)-c3ccnc4n(C)ccc34)nn2CC1=O

InChI Key InChIKey=ZSHGHYUYXCOMLK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500634   

LigandPNGBDBM500634(US11021481, Compound I-294 | 6-methyl-2- ((7-(1-me...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500634(US11021481, Compound I-294 | 6-methyl-2- ((7-(1-me...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500634(US11021481, Compound I-294 | 6-methyl-2- ((7-(1-me...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500634(US11021481, Compound I-294 | 6-methyl-2- ((7-(1-me...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500634(US11021481, Compound I-294 | 6-methyl-2- ((7-(1-me...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent